Ohio Benefits Group

  • Home
  • Medicare Made Simple
  • Travel/Health Insurance
  • Long Term Care Insurance
    • Senior Home Safety
  • Benefits Blog
  • Health Care for the Individual and Employeer
  • Pension Max/Life
  • Colonial Life

Aluminum and Alzheimer's Disease

4/12/2021

0 Comments

 
Aluminum Is Intricately Associated with the Neuropathology of Familial Alzheimer’s Disease
​APRIL 9, 2021
Keele, UK – A new study published in the Journal of Alzheimer’s Disease Reports continues to support a growing body of evidence that aluminum contributes to the pathogenesis of Alzheimer’s disease (AD). Researchers found aluminum co-located with phosphorylated tau protein, which is an early initiator of AD. This study builds upon two earlier published studies (including Mold et al., 2020, Journal of Alzheimer’s Disease) from the same group. The new data demonstrate that aluminum is co-located with phosphorylated tau protein, present as tangles within neurons in the brains of early-onset or familial Alzheimer’s disease. “The presence of these tangles is associated with neuronal cell death, and observations of aluminum in these tangles may highlight a role for aluminum in their formation,” explained lead investigator Matthew John Mold, PhD, Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.


The earlier research highlighted widespread co-localization of aluminum and amyloid-β in brain tissue in familial AD. The researchers used a highly-selective method of immunolabelling in the current study, combined with aluminum-specific fluorescence microscopy. Phosphorylated tau in tangles co-located with aluminum in the brain tissue of the same cohort of Colombian donors with familial AD were identified. “It is of interest and perhaps significance with respect to aluminum’s role in AD that its unequivocal association with tau is not as easily recognizable as with amyloid-β. There are many more aggregates of aluminum with amyloid-β than with tau in these tissues and the latter are predominantly intracellular,” remarked co-author, Professor Christopher Exley.



George Perry, PhD, Editor-in-Chief of the Journal of Alzheimer’s Disease, comments: “Aluminum accumulation has been associated with Alzheimer’s disease for nearly half a century, but it is the meticulously specific studies of Drs. Mold and Exley that are defining the exact molecular interaction of aluminum and other multivalent metals that may be critical to formation of the pathology of Alzheimer’s disease.”
“The new data may suggest that the association of aluminum with extracellular senile plaques precedes that with intracellular aggregates of tau. These relationships with both amyloid-β and tau may account for the high levels of aluminum observed in the brain tissue of donors with familial AD versus those without a diagnosis of neurodegenerative disease,” said Dr. Mold. “Tau and amyloid-beta are known to act in synergy to produce neurotoxicity in AD and our data provide new evidence for a role of aluminum in this process.”
###
Picture
The image shows aluminum (orange) in a neuron in a donor’s brain tissue with familial AD. The same neuron revealed positive immunostaining (brown) for phosphorylated tau (pTau). Merging these images showed that aluminum and pTau are co-located inside the same cell.
​https://www.iospress.nl/ios_news/aluminum-is-intricately-associated-with-the-neuropathology-of-familial-alzheimers-disease/?utm_source=join1440&utm_medium=email
0 Comments



Leave a Reply.

    Author

    Benefits Specialist, emphasis on Healthcare and  Long Term Care Insurance

    Archives

    December 2022
    November 2022
    September 2022
    June 2022
    May 2022
    September 2021
    July 2021
    April 2021
    February 2021
    October 2020
    August 2020
    July 2020
    June 2020
    May 2020
    January 2020
    April 2019
    January 2019
    October 2018
    June 2018
    May 2018
    March 2018
    February 2018
    January 2018
    April 2017
    June 2016
    May 2016
    February 2016
    January 2016
    December 2015
    November 2015
    February 2015
    January 2015
    July 2014
    December 2013
    March 2013
    January 2013
    December 2012

    Categories

    All
    Long Term Care Insurance
    Policy
    Premium Increase
    Sex Distinct
    Women

    RSS Feed

Powered by Create your own unique website with customizable templates.